| Comments |
Restriction digests of the clone give the following sizes (kb): PstI--5.15; BamHI--4.5, 0.68; HindIII--2.7, 2.4; EcoRI--3.2, 1.4, 0.58. Linked to the Lowe oculocerebrorenal syndrome (OCRL), theta = 0.03 and LOD score = 7.07. Insert is next to probe 6A-1 in the genome but does not detect the constant band (3.5 kb) detected by 6A-1. Enzyme(s) not detecting polymorphism: HindIII, MspI, EcoRI, BglII. |
| References |
Boggs BA, Nussbaum RL. Two anonymous X-specific human sequences detecting RFLPs in region Xq26-qter. Somatic Cell Mol. Genet. 10: 607-613, 1984. PubMed: 6095463
Reilly DS, et al. Genetic and physical mapping of Xq24-q26 markers flanking the Lowe oculocerebrorenal syndrome. Genomics 8: 62-70, 1990. PubMed: 2081601
Reilly DS, et al. Tightly linked flanking markers for the Lowe oculocerebrorenal syndrome, with application to carrier assessment. Am. J. Hum. Genet. 42: 748-755, 1988. PubMed: 2895982
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