Monoclonal Anti-Human Interferon Beta Protein, Clone A5 (produced in vitro)
商品貨號
B188213
Agent
Monoclonal Anti-Human Interferon Beta Protein, Clone A5 (produced in vitro)
Biosafety Level
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format
frozen
Storage Conditions
-20°C or colder. Repeated freeze-thaw cycles should be avoided.
Comments
Antibody Class: IgAk
The B cell hybridoma was generated by the fusion of P3X63Ag8.653 myeloma cells with splenocytes from a BALB/c x DBA F1 mouse immunized repeatedly with recombinant human IFN-β protein in adjuvant.
The clone A5 antibody is specific for human IFN-β and does not cross-react with IFN-α or IFN-γ.
Name of Depositor
SE Grossberg, Medical College of Wisconsin
Source
Mouse monoclonal antibody prepared against a recombinant form of the human interferon beta protein was purified from clone A5 hybridoma supernatant using a protein-free thiophilic adsorbent.
References
Redlich PN, SE Grossberg. Analysis of antigenic domains on natural and recombinant human IFN-β by the inhibition of biologic activities with monoclonal antibodies. J. Immunol. 143: 1887-1893, 1989. PubMed: 2476486
Runkel L, et al. Mapping of IFN-β epitopes important for receptor binding and biologic activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesis. J. Interferon Cytokine Res. 21: 931-941, 2001. PubMed: 11747625
