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GB virus B

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編號:B163211

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產品名稱	GB virus B
商品貨號	B163211
Classification	Flaviviridae
Deposited As	Hepatitis virus (unclassified)
Agent	GB virus B
Strain	GB
Biosafety Level	2 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Isolation	Agent detected in tamarins injected with acute phase serum from a human male with viral hepatitis
Product Format	frozen 1 mL per vial
Storage Conditions	-70°C or colder
Comments	Originally believed to be a human virus but now assumed to be a tamarin virus Infectivity stable at 50°C for 30 minutes (partially inactivated at 60°C for 1 hour). The GB agent is distinct from hepatitis A and B. The GB isolate may have two components (GB-A & GB-B). It is different from the MS-1, reference hepatitis A strain. Originally believed to be a human hepatitis. The vial contains acute phase serum from tamarin monkeys infected with the virus
Effect on Host	Enzymatic and histologically typical viral hepatitis
Recommended Host	Saguinus mystax (moustached tamarin)
Growth Conditions	Incubation: 14-28 days
Name of Depositor	F Deinhardt
Source	Agent detected in tamarins injected with acute phase serum from a human male with viral hepatitis
References	Deinhardt F, et al. Studies on the transmission of human viral hepatitis to marmoset monkeys. I. Transmission of disease, serial passages, and description of liver lesions. J. Exp. Med. 125: 673-688, 1967. PubMed: 4960092 Deinhardt F, et al. Hepatitis in marmosets. Am. J. Med. Sci. 270: 73-80, 1975. PubMed: 171953 Beames B, et al. Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. J. Virol. 74: 11764-11772, 2000. PubMed: 11090176 Simons JN, et al. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc. Natl. Acad. Sci. USA 92: 3401-3405, 1995. PubMed: 7724574

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